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human GRWD1 shRNA silencing AAV

Name 
AAV-h-GRWD1-shRNA
Cat No 
shAAV-210569
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human GRWD1.

shAAV-210569
AAV-h-GRWD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GRWD1 (glutamate rich WD repeat containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CDW4; CUL4- and DDB1-associated WDR protein 4; glutamate rich WD repeat protein GRWD; glutamate-rich WD repeat-containing protein 1; GRWD; regulator of ribosome biogenesis 1 homolog; RRB1; WD repeat domain 28; WDR28
Description (eCommerce)
GRWD1/WDR28 contains five WD repeats and is a member of the WD family of proteins. The WD repeat is defined by four or more repeating units of a conserved core of approximately 40 amino acids ending with tryptophan-aspartic acid (WD). WD repeats may serve as sites of protein-protein interaction for adaptor proteins and facilitate multiprotein complex formation. WD proteins are involved in a variety of cellular processes. GRWD1/WDR28 is proposed to play a role in ribosome biogenesis.
Description (Vector)
GRWD1 encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase.
Gene ID
83743
Gene Name (eCommerce)
glutamate rich WD repeat containing 1
Gene Name (Vector)
glutamate rich WD repeat containing 1
Gene Symbol
GRWD1
HGNC ID
HGNC:21270
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1341
ORF Size (bp)
1341 bp
Protein Name (eCommerce)
Glutamate-rich WD repeat-containing protein 1
RefSeq ID
NM_031485
RefSeq Synonyms
NM_031485, BC002440,
Research Areas
Cell Biology,Translational Control
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
GRWD1/WDR28 contains five WD repeats and is a member of the WD family of proteins. The WD repeat is defined by four or more repeating units of a conserved core of approximately 40 amino acids ending with tryptophan-aspartic acid (WD). WD repeats may serve as sites of protein-protein interaction for adaptor proteins and facilitate multiprotein complex formation. WD proteins are involved in a variety of cellular processes. GRWD1/WDR28 is proposed to play a role in ribosome biogenesis.
UniGene ID
Hs.400625
UniProt ID (eCommerce)
Q9BQ67

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.