human GRM2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GRM2.
shAAV-210547
AAV-h-GRM2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GRM2 (glutamate metabotropic receptor 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GLUR2; GPRC1B; mGlu2; MGLUR2
Description (Vector)
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
2912
Gene Name (Vector)
glutamate metabotropic receptor 2
Gene Symbol
GRM2
HGNC ID
HGNC:4594
ORF Size (aa)
2619
ORF Size (bp)
2619 bp
RefSeq ID
NM_000839
RefSeq Synonyms
NM_001130063, NM_000839, BC113619, BC113615,
Species
human
UniGene ID
Hs.121510
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.