human GRIN1 shRNA silencing AAV

Name
AAV-h-GRIN1-shRNA

Cat No
shAAV-210521

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human GRIN1.

shAAV-210521

AAV-h-GRIN1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GluN1; MRD8; NMD-R1; NMDA1; NMDAR1; NR1

Description (Vector)

GRIN1 is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

Gene ID

2902

Gene Name (Vector)

glutamate ionotropic receptor NMDA type subunit 1

Gene Symbol

GRIN1

HGNC ID

HGNC:4584

ORF Size (aa)

2814

ORF Size (bp)

2814 bp

RefSeq ID

NM_000832

RefSeq Synonyms

NM_021569, NM_007327, NM_001185091, NM_001185090, NM_000832, BC156961, BC156097,

Species

human

UniGene ID

Hs.558334

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.