human GPRASP1 shRNA silencing AAV

Name
AAV-h-GPRASP1-shRNA

Cat No
shAAV-210423

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human GPRASP1.

shAAV-210423

AAV-h-GPRASP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GPRASP1 (G protein-coupled receptor associated sorting protein 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GASP; GASP-1; GASP1

Description (Vector)

GPRASP1 encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified.

Gene ID

9737

Gene Name (Vector)

G protein-coupled receptor associated sorting protein 1

Gene Symbol

GPRASP1

HGNC ID

HGNC:24834

ORF Size (aa)

4188

ORF Size (bp)

4188 bp

RefSeq ID

NM_014710

RefSeq Synonyms

NM_014710, NM_001184727, NM_001099411, NM_001099410, BC114552,

Species

human

UniGene ID

Hs.710048

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.