human GPR56 shRNA silencing AAV

Name
AAV-h-GPR56-shRNA

Cat No
shAAV-210371

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ADGRG1.

shAAV-210371

AAV-h-GPR56-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ADGRG1 (adhesion G protein-coupled receptor G1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BFPP; BPPR; GPR56; TM7LN4; TM7XN1

Description (Vector)

GPR56 encodes a member of the G protein-coupled receptor family. The protein contains 7 transmembrane domains and a mucin-like domain in the N-terminal region. The gene is implicated in the regulation of brain cortical patterning. The protein binds specifically to transglutaminase 2 in the extracellular space. Expression of this gene is downregulated in melanoma cell lines, and overexpression of this gene can suppress tumor growth and metastasis. Mutations in this gene result in bilateral frontoparietal polymicrogyria. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

9289

Gene Name (Vector)

adhesion G protein-coupled receptor G1

Gene Symbol

ADGRG1

HGNC ID

HGNC:4512

ORF Size (aa)

2082

ORF Size (bp)

2082 bp

RefSeq ID

NM_005682

RefSeq Synonyms

NM_201525, NM_201524, NM_005682, NM_001290144, NM_001290143, NM_001290142, NM_001145774, NM_001145773, NM_001145772, NM_001145771, NM_001145770, BC008770,

Species

human

UniGene ID

Hs.513633

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.