human GPNMB shRNA silencing AAV

Name
AAV-h-GPNMB-shRNA

Cat No
shAAV-210248

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human GPNMB.

shAAV-210248

AAV-h-GPNMB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GPNMB (glycoprotein nmb). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HGFIN; NMB

Description (Vector)

GPNMB is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

10457

Gene Name (Vector)

glycoprotein nmb

Gene Symbol

GPNMB

HGNC ID

HGNC:4462

ORF Size (aa)

1719

ORF Size (bp)

1719 bp

RefSeq ID

NM_002510

RefSeq Synonyms

NM_002510, NM_001005340, BC032783,

Species

human

UniGene ID

Hs.190495

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.