human GNL3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GNL3.
shAAV-210127
AAV-h-GNL3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GNL3 (G protein nucleolar 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C77032; E2IG3; E2-induced gene 3 protein; estradiol-induced nucleotide binding protein; guanine nucleotide binding protein-like 3 (nucleolar); guanine nucleotide-binding protein-like 3; NNP47; novel nucleolar protein 47; NS; nucleolar GTP-binding protein 3; nucleostemin
Description (eCommerce)
GNL3 (guanine nucleotide binding protein-like 3), also known as nucleostemin (NS), was identified as a protein highly expressed in stem cells and downregulated in differentiated cells.GNL3 has also been found to be highly expressed in some cancer cell lines, and may play an important role in the control of cell proliferation. GNL3 functions as a GTPase and functions in the processing of nucleolar pre-rRNA.
Description (Vector)
GNL3 may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene.
Gene ID
26354
Gene Name (eCommerce)
G protein nucleolar 3
Gene Name (Vector)
G protein nucleolar 3
Gene Symbol
GNL3
HGNC ID
HGNC:29931
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1650
ORF Size (bp)
1650 bp
Protein Name (eCommerce)
Guanine nucleotide-binding protein-like 3
RefSeq ID
NM_206826
RefSeq Synonyms
NM_206826, NM_206825, NM_014366, BC001024,
Research Areas
Cancer,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer
Species
human
Target Sentence
GNL3 (guanine nucleotide binding protein-like 3), also known as nucleostemin (NS), was identified as a protein highly expressed in stem cells and downregulated in differentiated cells.GNL3 has also been found to be highly expressed in some cancer cell lines, and may play an important role in the control of cell proliferation. GNL3 functions as a GTPase and functions in the processing of nucleolar pre-rRNA.
UniGene ID
Hs.313544
UniProt ID (eCommerce)
Q9BVP2
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.