human GMEB2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GMEB2.
shAAV-210035
AAV-h-GMEB2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GMEB2 (glucocorticoid modulatory element binding protein 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DNA-binding protein p79PIF; glucocorticoid modulatory element-binding protein 2; GMEB-2; P79PIF; Parvovirus initiation factor p79; parvovirus initiation factor, p79; PIF p79; PIF79
Description (eCommerce)
Glucocorticoid modulatory element-binding protein 2 (GMEB2) is a trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. GMEB2 also binds to the transferrin receptor promoter and is an essential auxiliary factor for the replication of parvoviruses [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9UKD1].
Description (Vector)
GMEB2 is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. GMEB2 appears to use multiple polyadenylation sites.
Gene ID
26205
Gene Name (eCommerce)
glucocorticoid modulatory element binding protein 2
Gene Name (Vector)
glucocorticoid modulatory element binding protein 2
Gene Symbol
GMEB2
HGNC ID
HGNC:4371
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1593
ORF Size (bp)
1593 bp
Protein Name (eCommerce)
Glucocorticoid modulatory element-binding protein 2
RefSeq ID
NM_012384
RefSeq Synonyms
NM_012384, BC036305,
Research Areas
Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
Glucocorticoid modulatory element-binding protein 2 (GMEB2) is a trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. GMEB2 also binds to the transferrin receptor promoter and is an essential auxiliary factor for the replication of parvoviruses [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9UKD1].
UniGene ID
Hs.473286
UniProt ID (eCommerce)
Q9UKD1
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.