human GLUL shRNA silencing AAV

Name 
AAV-h-GLUL-shRNA
Cat No 
shAAV-210021
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human GLUL.

shAAV-210021
AAV-h-GLUL-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GLUL (glutamate-ammonia ligase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
cell proliferation-inducing protein 59; GLNS; glutamate decarboxylase; Glutamate--ammonia ligase; glutamine synthase; glutamine synthetase; GS; PIG43; PIG59; proliferation-inducing protein 43
Description (eCommerce)
GLUL/Glutamine Synthetase belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation [taken from NCBI Entrez Gene (Gene ID: 2752)].
Description (Vector)
GLUL belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling. This gene is expressed during early fetal stages, and plays an important role in controlling body pH by removing ammonia from circulation. Mutations in this gene are associated with congenital glutamine deficiency. Several alternatively spliced transcript variants have been found for this gene.
Gene ID
2752
Gene Name (eCommerce)
glutamate-ammonia ligase
Gene Name (Vector)
glutamate-ammonia ligase
Gene Symbol
GLUL
HGNC ID
HGNC:4341
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1122
ORF Size (bp)
1122 bp
Protein Name (eCommerce)
Glutamine synthetase
RefSeq ID
NM_002065
RefSeq Synonyms
NM_002065, NM_001033056, NM_001033044, BC051726, BC031964, BC018992, BC011852, BC011700, BC010037,
Research Areas
Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Signal Transduction,TNF Signaling
Research Areas (Faceted)
cell_biology,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
GLUL/Glutamine Synthetase belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation [taken from NCBI Entrez Gene (Gene ID: 2752)].
UniGene ID
Hs.518525
UniProt ID (eCommerce)
P15104

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.