human GLRB shRNA silencing AAV

Name 
AAV-h-GLRB-shRNA
Cat No 
shAAV-209994
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human GLRB.

shAAV-209994
AAV-h-GLRB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GLRB (glycine receptor beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
HKPX2
Description (Vector)
GLRB encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants.
Gene ID
2743
Gene Name (Vector)
glycine receptor beta
Gene Symbol
GLRB
HGNC ID
HGNC:4329
ORF Size (aa)
1494
ORF Size (bp)
1494 bp
RefSeq ID
NM_000824
RefSeq Synonyms
NM_001166061, NM_001166060, NM_000824, BC032635,
Species
human
UniGene ID
Hs.32973

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.