human GIGYF1 shRNA silencing AAV

Name
AAV-h-GIGYF1-shRNA

Cat No
shAAV-209874

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human GIGYF1.

shAAV-209874

AAV-h-GIGYF1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GIGYF1 (GRB10 interacting GYF protein 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

70

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GRB10-interacting GYF protein 1; GYF1; PERQ amino acid-rich with GYF domain-containing protein 1; PERQ1; postmeiotic segregation increased 2-like 12

Description (eCommerce)

PERQ amino acid-rich with GYF domain-containing protein 1 (GIGYF1) may act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. GIGYF1 may increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75420].

Gene ID

64599

Gene Name (eCommerce)

GRB10 interacting GYF protein 1

Gene Name (Vector)

GRB10 interacting GYF protein 1

Gene Symbol

GIGYF1

HGNC ID

HGNC:9126

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3108

ORF Size (bp)

3108 bp

Protein Name (eCommerce)

PERQ amino acid-rich with GYF domain-containing protein 1

RefSeq ID

NM_022574

RefSeq Synonyms

NM_022574, BC172395,

Research Areas

Signal Transduction

Research Areas (Faceted)

signal_transduction

Species

human

Target Sentence

PERQ amino acid-rich with GYF domain-containing protein 1 (GIGYF1) may act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. GIGYF1 may increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75420].

UniGene ID

Hs.603768

UniProt ID (eCommerce)

O75420

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.