human GHSR shRNA silencing AAV

Name
AAV-h-GHSR-shRNA

Cat No
shAAV-209871

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human GHSR.

shAAV-209871

AAV-h-GHSR-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GHSR (growth hormone secretagogue receptor). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GHDP

Description (Vector)

GHSR encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.

Gene ID

2693

Gene Name (Vector)

growth hormone secretagogue receptor

Gene Symbol

GHSR

HGNC ID

HGNC:4267

ORF Size (aa)

870

ORF Size (bp)

870 bp

RefSeq ID

NM_004122

RefSeq Synonyms

NM_198407, NM_004122, BC113547, BC069374, BC069068,

Species

human

UniGene ID

Hs.248115

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.