human GHR shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GHR.
shAAV-209864
AAV-h-GHR-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GHR (growth hormone receptor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GHBP;
Description (Vector)
GHR encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.
Gene ID
2690
Gene Name (Vector)
growth hormone receptor
Gene Symbol
GHR
HGNC ID
HGNC:4263
ORF Size (aa)
1356
ORF Size (bp)
1356 bp
RefSeq ID
NM_000163
RefSeq Synonyms
NM_001242462, NM_001242461, NM_001242460, NM_001242406, NM_001242405, NM_001242404, NM_001242403, NM_001242402, NM_001242401, NM_001242400, NM_001242399, NM_000163, BC136496,
Species
human
UniGene ID
Hs.684631
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.