human GDF5 shRNA silencing AAV

Name
AAV-h-GDF5-shRNA

Cat No
shAAV-209779

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human GDF5.

shAAV-209779

AAV-h-GDF5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GDF5 (growth differentiation factor 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BDA1C; BMP-14; BMP14; CDMP1; LAP-4; LAP4; OS5; SYM1B; SYNS2

Description (Vector)

GDF5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.

Gene ID

8200

Gene Name (Vector)

growth differentiation factor 5

Gene Symbol

GDF5

HGNC ID

HGNC:4220

ORF Size (aa)

1506

ORF Size (bp)

1506 bp

RefSeq ID

NM_000557

RefSeq Synonyms

NM_001319138, NM_000557, BC032495,

Species

human

UniGene ID

Hs.1573

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.