human GAPVD1 shRNA silencing AAV

Name
AAV-h-GAPVD1-shRNA

Cat No
shAAV-209643

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human GAPVD1.

shAAV-209643

AAV-h-GAPVD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GAPVD1 (GTPase activating protein and VPS9 domains 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GAPEX5; GAPex-5; GTPase-activating protein and VPS9 domain-containing protein 1; Rab5 exchange factor; Rab5-activating protein 6; RAP6

Description (eCommerce)

GAPex-5 was identified in a two-hybrid screen for interactors of CIP4 (Cdc42 interacting protein 4). GAPex-5 contains a Ras-GAP domain and a VPS9 (vacuolar sorting protein 9 (VPS9) domain. It functions as a GEF for RAB31 to influence GLUT4 trafficking. It has also been found to be involved in the trafficking and ubiquitination of EGFR.

Gene ID

26130

Gene Name (eCommerce)

GTPase activating protein and VPS9 domains 1

Gene Name (Vector)

GTPase activating protein and VPS9 domains 1

Gene Symbol

GAPVD1

HGNC ID

HGNC:23375

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

4302

ORF Size (bp)

4302 bp

Protein Name (eCommerce)

GTPase-activating protein and VPS9 domain-containing protein 1

RefSeq ID

NM_015635

RefSeq Synonyms

NM_015635, NM_001330778, NM_001330777, NM_001282681, NM_001282680, NM_001282679, BC114962, BC114937,

Research Areas

Signal Transduction,Transport

Research Areas (Faceted)

signal_transduction,cell_biology

Species

human

Target Sentence

GAPex-5 was identified in a two-hybrid screen for interactors of CIP4 (Cdc42 interacting protein 4). GAPex-5 contains a Ras-GAP domain and a VPS9 (vacuolar sorting protein 9 (VPS9) domain. It functions as a GEF for RAB31 to influence GLUT4 trafficking. It has also been found to be involved in the trafficking and ubiquitination of EGFR.

UniGene ID

Hs.495134

UniProt ID (eCommerce)

Q14C86

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.