human GABRB3 shRNA silencing AAV

Name
AAV-h-GABRB3-shRNA

Cat No
shAAV-209520

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human GABRB3.

shAAV-209520

AAV-h-GABRB3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GABRB3 (gamma-aminobutyric acid type A receptor beta3 subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ECA5; EIEE43

Description (Vector)

GABRB3 encodes a member of the ligand-gated ionic channel family. The encoded protein is one of at least 13 distinct subunits of a multisubunit chloride channel that serves as the receptor for gamma-aminobutyric acid, the major inhibitory transmitter of the nervous system. GABRB3 is located on the long arm of chromosome 15 in a cluster with two genes encoding related subunits of the family. Mutations in this gene may be associated with the pathogenesis of Angelman syndrome, Prader-Willi syndrome, and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Gene ID

2562

Gene Name (Vector)

gamma-aminobutyric acid type A receptor beta3 subunit

Gene Symbol

GABRB3

HGNC ID

HGNC:4083

ORF Size (aa)

1422

ORF Size (bp)

1422 bp

RefSeq ID

NM_000814

RefSeq Synonyms

NM_021912, NM_001278631, NM_001191321, NM_001191320, NM_000814, BC010641,

Species

human

UniGene ID

Hs.657298

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.