human GAB2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GAB2.
shAAV-209488
AAV-h-GAB2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GAB2 (GRB2 associated binding protein 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
GAB2 is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
Gene ID
9846
Gene Name (Vector)
GRB2 associated binding protein 2
Gene Symbol
GAB2
HGNC ID
HGNC:14458
ORF Size (aa)
2031
ORF Size (bp)
2031 bp
RefSeq ID
NM_012296
RefSeq Synonyms
NM_080491, NM_012296, BC152459, BC131711,
Species
human
UniGene ID
Hs.429434
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.