human GAB1 shRNA silencing AAV

Name
AAV-h-GAB1-shRNA

Cat No
shAAV-209486

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human GAB1.

shAAV-209486

AAV-h-GAB1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GAB1 (GRB2 associated binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DFNB26; GRB2-associated binder 1; GRB2-associated-binding protein 1; growth factor receptor bound protein 2-associated protein 1

Description (eCommerce)

GRB2-associated-binding protein 1 (GAB1) is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis [taken from NCBI Entrez Gene (Gene ID: 2549)].

Description (Vector)

GAB1 is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

2549

Gene Name (eCommerce)

GRB2 associated binding protein 1

Gene Name (Vector)

GRB2 associated binding protein 1

Gene Symbol

GAB1

HGNC ID

HGNC:4066

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2175

ORF Size (bp)

2175 bp

Protein Name (eCommerce)

GRB2-associated-binding protein 1

RefSeq ID

NM_002039

RefSeq Synonyms

NM_207123, NM_002039, BC064848,

Research Areas

B-cell Receptor Signaling,Breast Cancer,Cancer,Cardiac Development,Cardiology,Cardiovascular,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Fc Receptor Signaling,FGF Signaling,Glioma,HGF Signaling,IGF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,Kidney Cancer,MAPK Signaling,Neurobiology,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,Prostate Cancer,SCF-KIT Signaling,Signal Transduction,TNF Signaling,VEGF Signaling

Research Areas (Faceted)

cancer,cardiovascular,developmental_biology,immunology,neurobiology,signal_transduction,stem_cell_biology

Species

human

Target Sentence

GRB2-associated-binding protein 1 (GAB1) is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis [taken from NCBI Entrez Gene (Gene ID: 2549)].

UniGene ID

Hs.618456

UniProt ID (eCommerce)

Q13480

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.