human FZD8 shRNA silencing AAV

Name
AAV-h-FZD8-shRNA

Cat No
shAAV-209470

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human FZD8.

shAAV-209470

AAV-h-FZD8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FZD8 (frizzled class receptor 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

FZ-8; hFZ8

Description (Vector)

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.

Gene ID

8325

Gene Name (Vector)

frizzled class receptor 8

Gene Symbol

FZD8

HGNC ID

HGNC:4046

ORF Size (aa)

2082

ORF Size (bp)

2082 bp

RefSeq ID

NM_031866

RefSeq Synonyms

NM_031866, BC111845,

Species

human

UniGene ID

Hs.302634

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.