human FUS shRNA silencing AAV

Name 
AAV-h-FUS-shRNA
Cat No 
shAAV-209408
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human FUS.

shAAV-209408
AAV-h-FUS-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FUS (FUS RNA binding protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
75 kDa DNA-pairing protein; ALS6; ETM4; FUS/ERG chimeric protein; FUS/ERG fusion protein; FUS1; fused in sarcoma; fusion gene in myxoid liposarcoma; fus-like protein; heterogeneous nuclear ribonucleoprotein P2; HNRNPP2; oncogene FUS; oncogene TLS; POMP75; RNA-binding protein FUS; TLS; translocated in liposarcoma protein
Description (eCommerce)
FUS has been identified as a frequent translocation fusion partner of various transcription factors. FUS fusion genes have been shown to be associated with multiple tumor types which include liposarcoma, leukemia, histocytoma, and sarcoma. FUS is a multifunctional RNA-binding protein that associates with the nuclear matrix and Cajal bodies and appears to play a role in splicesome assembly, pre-mRNA splicing, DNA repair, transcriptional regulation and homologous recombination.
Description (Vector)
FUS encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
Gene ID
2521
Gene Name (eCommerce)
FUS RNA binding protein
Gene Name (Vector)
FUS RNA binding protein
Gene Symbol
FUS
HGNC ID
HGNC:4010
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1581
ORF Size (bp)
1581 bp
Protein Name (eCommerce)
RNA-binding protein FUS
RefSeq ID
NM_004960
RefSeq Synonyms
NM_004960, NM_001170937, NM_001170634, BC026062, BC002459, BC000402,
Research Areas
Amyotrophic Lateral Sclerosis (ALS),Apoptosis,Cancer,Gene Expression,mRNA Processing,mRNA Splicing,Neurobiology,Neurodegeneration,RNA Binding,RNA Processing,Spliceosome,Transcriptional Misregulation in Cancer,Tumor Suppressors/Oncoproteins,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation,neurobiology
Species
human
Target Sentence
FUS has been identified as a frequent translocation fusion partner of various transcription factors. FUS fusion genes have been shown to be associated with multiple tumor types which include liposarcoma, leukemia, histocytoma, and sarcoma. FUS is a multifunctional RNA-binding protein that associates with the nuclear matrix and Cajal bodies and appears to play a role in splicesome assembly, pre-mRNA splicing, DNA repair, transcriptional regulation and homologous recombination.
UniGene ID
Hs.513522
UniProt ID (eCommerce)
P35637

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.