human FREM1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human FREM1.
shAAV-209306
AAV-h-FREM1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human FREM1 (FRAS1 related extracellular matrix 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BNAR; C9orf143; C9orf145; C9orf154; MOTA; TILRR; TRIGNO2
Description (Vector)
FREM1 encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation.
Gene ID
158326
Gene Name (Vector)
FRAS1 related extracellular matrix 1
Gene Symbol
FREM1
HGNC ID
HGNC:23399
ORF Size (aa)
6537
ORF Size (bp)
6537 bp
RefSeq ID
NM_144966
RefSeq Synonyms
NM_144966, NM_001177704, BC172226,
Species
human
UniGene ID
Hs.709555
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.