human FIG4 shRNA silencing AAV

Name
AAV-h-FIG4-shRNA

Cat No
shAAV-209027

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human FIG4.

shAAV-209027

AAV-h-FIG4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FIG4 (FIG4 phosphoinositide 5-phosphatase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ALS11; BTOP; CMT4J; dJ249I4.1; KIAA0274; SAC3; YVS

Description (Vector)

FIG4 belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J.

Gene ID

9896

Gene Name (Vector)

FIG4 phosphoinositide 5-phosphatase

Gene Symbol

FIG4

HGNC ID

HGNC:16873

ORF Size (aa)

2724

ORF Size (bp)

2724 bp

RefSeq ID

NM_014845

RefSeq Synonyms

NM_014845, BC041338,

Species

human

UniGene ID

Hs.529959

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.