human FHL3 shRNA silencing AAV

Name
AAV-h-FHL3-shRNA

Cat No
shAAV-209015

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human FHL3.

shAAV-209015

AAV-h-FHL3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FHL3 (four and a half LIM domains 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

SLIM2

Description (Vector)

FHL3 is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

2275

Gene Name (Vector)

four and a half LIM domains 3

Gene Symbol

FHL3

HGNC ID

HGNC:3704

ORF Size (aa)

519

RefSeq ID

NM_004468

RefSeq Synonyms

NM_004468, NM_001243878, BC014501, BC011697, BC001351,

Species

human

UniGene ID

Hs.57687

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.