human FGG shRNA silencing AAV

Name
AAV-h-FGG-shRNA

Cat No
shAAV-208999

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human FGG.

shAAV-208999

AAV-h-FGG-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FGG (fibrinogen gamma chain). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

FGG is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.

Gene ID

2266

Gene Name (Vector)

fibrinogen gamma chain

Gene Symbol

FGG

HGNC ID

HGNC:3694

ORF Size (aa)

1314

ORF Size (bp)

1314 bp

RefSeq ID

NM_000509

RefSeq Synonyms

NM_021870, NM_000509, BC021674, BC007044,

Species

human

UniGene ID

Hs.546255

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.