human FGF8 shRNA silencing AAV

Name
AAV-h-FGF8-shRNA

Cat No
shAAV-208982

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human FGF8.

shAAV-208982

AAV-h-FGF8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FGF8 (fibroblast growth factor 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AIGF; FGF-8; HBGF-8; HH6; KAL6

Description (Vector)

FGF8 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.

Gene ID

2253

Gene Name (Vector)

fibroblast growth factor 8

Gene Symbol

FGF8

HGNC ID

HGNC:3686

ORF Size (aa)

735

ORF Size (bp)

735 bp

RefSeq ID

NM_006119

RefSeq Synonyms

NM_033165, NM_033164, NM_033163, NM_006119, NM_001206389, BC128236, BC128235, BC069106,

Species

human

UniGene ID

Hs.57710

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.