human FBXW5 shRNA silencing AAV

Name
AAV-h-FBXW5-shRNA

Cat No
shAAV-208837

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human FBXW5.

shAAV-208837

AAV-h-FBXW5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FBXW5 (F-box and WD repeat domain containing 5). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Fbw5

Description (Vector)

FBXW5 encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.

Gene ID

54461

Gene Name (Vector)

F-box and WD repeat domain containing 5

Gene Symbol

FBXW5

HGNC ID

HGNC:13613

ORF Size (aa)

1701

ORF Size (bp)

1701 bp

RefSeq ID

NM_018998

RefSeq Synonyms

NM_018998, BC014297, BC014130,

Species

human

UniGene ID

Hs.522507

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.