human EXOSC5 shRNA silencing AAV

Name 
AAV-h-EXOSC5-shRNA
Cat No 
shAAV-208192
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human EXOSC5.

shAAV-208192
AAV-h-EXOSC5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EXOSC5 (exosome component 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
chronic myelogenous leukemia tumor antigen 28; exosome complex component RRP46; exosome complex exonuclease RRP46; Exosome component 5; exosome component Rrp46; hRrp46p; p12B; ribosomal RNA-processing protein 46; RRP41B; RRP46; Rrp46p
Description (eCommerce)
EXOSC5 (exosome complex component RRP46) is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NQT4].
Gene ID
56915
Gene Name (eCommerce)
exosome component 5
Gene Name (Vector)
exosome component 5
Gene Symbol
EXOSC5
HGNC ID
HGNC:24662
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
708
ORF Size (bp)
708 bp
Protein Name (eCommerce)
Exosome complex component RRP46
RefSeq ID
NM_020158
RefSeq Synonyms
NM_020158, BC107696, BC007742,
Research Areas
Gene Expression,Host-Virus Interactions,mRNA Binding,Response to Virus,RNA Binding,RNA Processing,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,immunology,infectious_disease,transcription_translation
Species
human
Target Sentence
EXOSC5 (exosome complex component RRP46) is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NQT4].
UniGene ID
Hs.283741
UniProt ID (eCommerce)
Q9NQT4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.