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human EXOSC1 shRNA silencing AAV

Name 
AAV-h-EXOSC1-shRNA
Cat No 
shAAV-208185
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human EXOSC1.

shAAV-208185
AAV-h-EXOSC1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EXOSC1 (exosome component 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
3'-5' exoribonuclease CSL4 homolog; CGI-108; CSL4; Csl4p; exosomal core protein CSL4; exosome complex component CSL4; Exosome component 1; homolog of yeast exosomal core protein CSL4; p13; SKI4; Ski4p
Description (eCommerce)
EXOSC1 is a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association CSL4 with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46 [taken from NCBI Entrez Gene (Gene ID: 51013)].
Description (Vector)
EXOSC1 encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46.
Gene ID
51013
Gene Name (eCommerce)
exosome component 1
Gene Name (Vector)
exosome component 1
Gene Symbol
EXOSC1
HGNC ID
HGNC:17286
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
588
ORF Size (bp)
588 bp
Protein Name (eCommerce)
Exosome complex component CSL4
RefSeq ID
NM_016046
RefSeq Synonyms
NM_016046, NM_001318366, NM_001318365, NM_001318364, NM_001318363, NM_001318362, BC022067,
Research Areas
Gene Expression,mRNA Binding,RNA Binding,RNA Processing
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
EXOSC1 is a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association CSL4 with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46 [taken from NCBI Entrez Gene (Gene ID: 51013)].
UniGene ID
Hs.632089
UniProt ID (eCommerce)
Q9Y3B2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.