human ERAL1 shRNA silencing AAV

Name
AAV-h-ERAL1-shRNA

Cat No
shAAV-208036

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ERAL1.

shAAV-208036

AAV-h-ERAL1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ERAL1 (Era like 12S mitochondrial rRNA chaperone 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CEGA; conserved ERA-like GTPase; ERA; era (E. coli G-protein homolog)-like 1; Era G-protein-like 1; ERAL1A; ERAL1B; ERA-like protein 1; ERA-W; GTPase Era, mitochondrial; GTPase, human homolog of E. coli essential cell cycle protein Era; GTP-binding protein era homolog; hERA; H-ERA; HERA-A; HERA-B; PRLTS6

Description (eCommerce)

The protein GTPase Era, mitochondrial, is encoded by the gene ERAL1. GTPase Era binds to the 3' terminal stem loop of 12S mitochondrial rRNA and is required for proper assembly of the 28S small mitochondrial ribosomal subunit. Deletion of this gene has been shown to cause mitochondrial dysfunction, growth retardation, and apoptosis [taken from NCBI Entrez Gene (Gene ID: 26284)].

Gene ID

26284

Gene Name (eCommerce)

Era like 12S mitochondrial rRNA chaperone 1

Gene Name (Vector)

Era like 12S mitochondrial rRNA chaperone 1

Gene Symbol

ERAL1

HGNC ID

HGNC:3424

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1314

ORF Size (bp)

1314 bp

Protein Name (eCommerce)

GTPase Era, mitochondrial

RefSeq ID

NM_005702

RefSeq Synonyms

NM_005702, NM_001317986, NM_001317985, BC019094,

Research Areas

Breast Cancer,Cancer,Mitochondrion,RNA Binding

Research Areas (Faceted)

cancer,cell_biology

Species

human

Target Sentence

The protein GTPase Era, mitochondrial, is encoded by the gene ERAL1. GTPase Era binds to the 3' terminal stem loop of 12S mitochondrial rRNA and is required for proper assembly of the 28S small mitochondrial ribosomal subunit. Deletion of this gene has been shown to cause mitochondrial dysfunction, growth retardation, and apoptosis [taken from NCBI Entrez Gene (Gene ID: 26284)].

UniGene ID

Hs.3426

UniProt ID (eCommerce)

O75616

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.