human EPOR shRNA silencing AAV

Name
AAV-h-EPOR-shRNA

Cat No
shAAV-208018

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human EPOR.

shAAV-208018

AAV-h-EPOR-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EPOR (erythropoietin receptor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EPO-R

Description (Vector)

EPOR encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.

Gene ID

2057

Gene Name (Vector)

erythropoietin receptor

Gene Symbol

EPOR

HGNC ID

HGNC:3416

ORF Size (aa)

1527

ORF Size (bp)

1527 bp

RefSeq ID

NM_000121

RefSeq Synonyms

NM_000121, BC112153,

Species

human

UniGene ID

Hs.631624

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.