human EPN1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human EPN1.
shAAV-208011
AAV-h-EPN1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human EPN1 (epsin 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
EH domain-binding mitotic phosphoprotein; EPS-15-interacting protein 1; epsin-1
Description (eCommerce)
Epsin 1 binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Epsin 1 regulates receptor-mediated endocytosis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y6I3].
Description (Vector)
EPN1 binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene.
Gene ID
29924
Gene Name (eCommerce)
epsin 1
Gene Name (Vector)
epsin 1
Gene Symbol
EPN1
HGNC ID
HGNC:21604
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1653
ORF Size (bp)
1653 bp
Protein Name (eCommerce)
Epsin-1
RefSeq ID
NM_013333
RefSeq Synonyms
NM_013333, NM_001321263, NM_001130072, NM_001130071, BC044651,
Research Areas
Cancer,EGFR Signaling,EGFR Signaling in Cancer,Notch Signaling,Signal Transduction,Transcription Factor/Regulator,Transport
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,signal_transduction,transcription_translation
Species
human
Target Sentence
Epsin 1 binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Epsin 1 regulates receptor-mediated endocytosis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y6I3].
UniGene ID
Hs.279953
UniProt ID (eCommerce)
Q9Y6I3
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.