human EML4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human EML4.
shAAV-207888
AAV-h-EML4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human EML4 (echinoderm microtubule associated protein like 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C2orf2; echinoderm microtubule-associated protein-like 4; ELP120; EMAP-4; EMAPL4; restrictedly overexpressed proliferation-associated protein; ropp 120; ROPP120
Description (eCommerce)
Echinoderm microtubule associated protein like 4 (EML4) has been identified as part of a gene fusion with the kinase domain of the anaplastic lymphoma receptor tyrosine kinase (ALK) in non-small cell lung cancer. EML4 associates with in vitro polymerized microtubules. In the cell, phosphorylated EML4 associates with the mitotic spindle and is essential for proliferation and microtubule network formation.
Gene ID
27436
Gene Name (eCommerce)
echinoderm microtubule associated protein like 4
Gene Name (Vector)
echinoderm microtubule associated protein like 4
Gene Symbol
EML4
HGNC ID
HGNC:1316
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2946
ORF Size (bp)
2946 bp
Protein Name (eCommerce)
Echinoderm microtubule-associated protein-like 4
RefSeq ID
NM_019063
RefSeq Synonyms
NM_019063, NM_001145076, BC146799, BC140845,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
Echinoderm microtubule associated protein like 4 (EML4) has been identified as part of a gene fusion with the kinase domain of the anaplastic lymphoma receptor tyrosine kinase (ALK) in non-small cell lung cancer. EML4 associates with in vitro polymerized microtubules. In the cell, phosphorylated EML4 associates with the mitotic spindle and is essential for proliferation and microtubule network formation.
UniGene ID
Hs.712760
UniProt ID (eCommerce)
Q9HC35
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.