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human ELF1 shRNA silencing AAV

Name 
AAV-h-ELF1-shRNA
Cat No 
shAAV-207832
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ELF1.

shAAV-207832
AAV-h-ELF1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ELF1 (E74 like ETS transcription factor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
E74-like factor 1; E74-like factor 1 (ets domain transcription factor); EFTUD1; ETS-related transcription factor Elf-1; RIA1
Description (eCommerce)
E74-like factor 1 (ELF1) is a member of the ETS (e26 transformation specific sequence) family of proteins, contains an ETS-domain, and shares sequence identity with the Drosophila ecdysone inducible E74 transcription factor. ETS was originally identified in the E26 retroviral isolate that led to the discovery of c-ets-1 (cellular ets-1), a cellular oncogenic transcription factor capable of transforming cells. Like ETS, ELF-1 functions as a transcription factor and has been shown to bind promoter and enhancer elements in a number of immunity responsive genes. ELF-1 is highly expressed in B-cells and appears to play an integral role in B-cell gene expression.
Description (Vector)
ELF1 encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants.
Gene ID
1997
Gene Name (eCommerce)
E74 like ETS transcription factor 1
Gene Name (Vector)
E74 like ETS transcription factor 1
Gene Symbol
ELF1
HGNC ID
HGNC:3316
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1860
ORF Size (bp)
1860 bp
Protein Name (eCommerce)
ETS-related transcription factor Elf-1
RefSeq ID
NM_172373
RefSeq Synonyms
NM_172373, NM_001145353, BC030507,
Research Areas
Cardiovascular,Immunology,Interleukin Signaling,Signal Transduction,T-cell Receptor Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cell_biology,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
E74-like factor 1 (ELF1) is a member of the ETS (e26 transformation specific sequence) family of proteins, contains an ETS-domain, and shares sequence identity with the Drosophila ecdysone inducible E74 transcription factor. ETS was originally identified in the E26 retroviral isolate that led to the discovery of c-ets-1 (cellular ets-1), a cellular oncogenic transcription factor capable of transforming cells. Like ETS, ELF-1 functions as a transcription factor and has been shown to bind promoter and enhancer elements in a number of immunity responsive genes. ELF-1 is highly expressed in B-cells and appears to play an integral role in B-cell gene expression.
UniGene ID
Hs.135646
UniProt ID (eCommerce)
P32519

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.