human EIF4EBP1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human EIF4EBP1.
shAAV-207787
AAV-h-EIF4EBP1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4EBP1; 4E-BP1; BP-1; eIF4E-binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; PHAS-I; phosphorylated heat- and acid-stable protein regulated by insulin 1
Description (eCommerce)
Eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) binds directly to eIF4E to inhibit complex assembly for translation initiation. 4EBP1 is part of a family of translation repressor proteins. 4EBP1 is directly phosphorylated by the mTORC1 complex during growth factor stimulation of cells. Phosphorylation of 4EBP1 causes its release from eIF4E to allow translation to proceed.
Description (Vector)
EIF4EBP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Gene ID
1978
Gene Name (eCommerce)
eukaryotic translation initiation factor 4E binding protein 1
Gene Name (Vector)
eukaryotic translation initiation factor 4E binding protein 1
Gene Symbol
EIF4EBP1
HGNC ID
HGNC:3288
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
357
Protein Name (eCommerce)
Eukaryotic translation initiation factor 4E-binding protein 1
RefSeq ID
NM_004095
RefSeq Synonyms
NM_004095, BC058073, BC004459,
Research Areas
B-cell Receptor Signaling,BDNF Signaling,Breast Cancer,Cancer,Cell Cycle,EGFR Signaling,Gene Expression,HGF Signaling,HIF-1 Signaling,IFN Signaling,IGF-1 Signaling,Immunology,Insulin Signaling,Interleukin Signaling,Leptin Signaling,Leukemia,Metabolism/Metabolic Process,mRNA Binding,mTOR Signaling,Neurobiology,PI3K/Akt Signaling,Prolactin Signaling,Prostate Cancer,RNA Transport,SCF-KIT Signaling,Signal Transduction,Translational Control,TSLP Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation,immunology,metabolism,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
Eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) binds directly to eIF4E to inhibit complex assembly for translation initiation. 4EBP1 is part of a family of translation repressor proteins. 4EBP1 is directly phosphorylated by the mTORC1 complex during growth factor stimulation of cells. Phosphorylation of 4EBP1 causes its release from eIF4E to allow translation to proceed.
UniGene ID
Hs.411641
UniProt ID (eCommerce)
Q13541
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.