human EDN3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human EDN3.
shAAV-207568
AAV-h-EDN3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human EDN3 (endothelin 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ET3; HSCR4; MGC15067; MGC61498; WS4B;
Description (Vector)
EDN3 is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
Gene ID
1908
Gene Name (Vector)
endothelin 3
Gene Symbol
EDN3
HGNC ID
HGNC:3178
ORF Size (aa)
717
ORF Size (bp)
717 bp
RefSeq ID
NM_000114
RefSeq Synonyms
NM_207034, NM_207033, NM_207032, NM_001302456, NM_001302455, NM_000114, BC053866, BC008876,
Species
human
UniGene ID
Hs.1408
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.