human ECD shRNA silencing AAV

Name
AAV-h-ECD-shRNA

Cat No
shAAV-207524

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ECD.

shAAV-207524

AAV-h-ECD-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ECD (ecdysoneless cell cycle regulator). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ecdysoneless homolog; GCR2; HSGT1; human suppressor of GCR two; protein ecdysoneless homolog; protein SGT1; SGT1; suppressor of GCR2; suppressor of S. cerevisiae gcr2

Description (eCommerce)

SGT1 (suppressor of GCR2) is the human homolog of the Drosophila ecdysoneless protein. SGT1 is a novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes.

Gene ID

11319

Gene Name (eCommerce)

ecdysoneless cell cycle regulator

Gene Name (Vector)

ecdysoneless cell cycle regulator

Gene Symbol

ECD

HGNC ID

HGNC:17029

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1935

ORF Size (bp)

1935 bp

Protein Name (eCommerce)

Protein ecdysoneless homolog

RefSeq ID

NM_007265

RefSeq Synonyms

NM_007265, NM_001135753, NM_001135752, BC000721,

Research Areas

Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,transcription_translation

Species

human

Target Sentence

SGT1 (suppressor of GCR2) is the human homolog of the Drosophila ecdysoneless protein. SGT1 is a novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes.

UniGene ID

Hs.631822

UniProt ID (eCommerce)

O95905

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.