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human DYSF shRNA silencing AAV

Name 
AAV-h-DYSF-shRNA
Cat No 
shAAV-207485
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human DYSF.

shAAV-207485
AAV-h-DYSF-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DYSF (dysferlin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
FER1L1; LGMD2B; MMD1
Description (Vector)
DYSF belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Alternative splicing results in multiple transcript variants.
Gene ID
8291
Gene Name (Vector)
dysferlin
Gene Symbol
DYSF
HGNC ID
HGNC:3097
ORF Size (aa)
6243
ORF Size (bp)
6243 bp
RefSeq ID
NM_003494
RefSeq Synonyms
NM_003494, NM_001130987, NM_001130986, NM_001130985, NM_001130984, NM_001130983, NM_001130982, NM_001130981, NM_001130980, NM_001130979, NM_001130978, NM_001130977, NM_001130976, NM_001130455, BC172229,
Species
human
UniGene ID
Hs.252180

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.