human DUSP8 shRNA silencing AAV

Name
AAV-h-DUSP8-shRNA

Cat No
shAAV-207443

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human DUSP8.

shAAV-207443

AAV-h-DUSP8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DUSP8 (dual specificity phosphatase 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C11orf81; HB5; HVH-5; HVH8

Description (Vector)

DUSP8 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.

Gene ID

1850

Gene Name (Vector)

dual specificity phosphatase 8

Gene Symbol

DUSP8

HGNC ID

HGNC:3074

ORF Size (aa)

1878

ORF Size (bp)

1878 bp

RefSeq ID

NM_004420

RefSeq Synonyms

NM_004420, BC045110, BC038231,

Species

human

UniGene ID

Hs.41688

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.