human DTNB shRNA silencing AAV

Name
AAV-h-DTNB-shRNA

Cat No
shAAV-207373

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human DTNB.

shAAV-207373

AAV-h-DTNB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DTNB (dystrobrevin beta). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

DTNB encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene ID

1838

Gene Name (Vector)

dystrobrevin beta

Gene Symbol

DTNB

HGNC ID

HGNC:3058

ORF Size (aa)

1830

ORF Size (bp)

1830 bp

RefSeq ID

NM_021907

RefSeq Synonyms

NM_183361, NM_183360, NM_033148, NM_033147, NM_021907, NM_001320937, NM_001320936, NM_001320935, NM_001320934, NM_001320933, NM_001320932, NM_001256308, NM_001256304, NM_001256303, BC049366, BC016655,

Species

human

UniGene ID

Hs.307720

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.