human DPM2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DPM2.
shAAV-207284
AAV-h-DPM2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DPM2 (dolichyl-phosphate mannosyltransferase subunit 2, regulatory). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CDG1U
Description (Vector)
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1.
Gene ID
8818
Gene Name (Vector)
dolichyl-phosphate mannosyltransferase subunit 2, regulatory
Gene Symbol
DPM2
HGNC ID
HGNC:3006
ORF Size (aa)
207
RefSeq ID
NM_003863
RefSeq Synonyms
NM_003863, BC107863, BC015374, BC015233,
Species
human
UniGene ID
Hs.108973
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.