human DOCK11 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DOCK11.
shAAV-207224
AAV-h-DOCK11-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DOCK11 (dedicator of cytokinesis 11). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ACG; Activated Cdc42-associated guanine nucleotide exchange factor; Activated Cdc42-associated guanine nucleotide exchange factor, ACG; bB128O4.1; bB128O4.1.1 (novel protein); dedicator of cytokinesis protein 11; ZIZ2; zizimin2; zizimin-2
Description (eCommerce)
DOCK11 (dedicator of cytokinesis 11) is also known as zizimin-2. It is a DOCK180-related guanine nucleotide exchange factor (GEF) for the small GTPase, Cdc42. As a GEF, DOCK11 functions to catalyze the dissociation of GDP from the GTPase. Dissociation of GDP allows an exchange for GTP and subsequent downstream signaling by the GTPase.
Gene ID
139818
Gene Name (eCommerce)
dedicator of cytokinesis 11
Gene Name (Vector)
dedicator of cytokinesis 11
Gene Symbol
DOCK11
HGNC ID
HGNC:23483
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
6219
ORF Size (bp)
6219 bp
Protein Name (eCommerce)
Dedicator of cytokinesis protein 11
RefSeq ID
NM_144658
RefSeq Synonyms
NM_144658, BC156530,
Research Areas
Signal Transduction
Research Areas (Faceted)
signal_transduction
Species
human
Target Sentence
DOCK11 (dedicator of cytokinesis 11) is also known as zizimin-2. It is a DOCK180-related guanine nucleotide exchange factor (GEF) for the small GTPase, Cdc42. As a GEF, DOCK11 functions to catalyze the dissociation of GDP from the GTPase. Dissociation of GDP allows an exchange for GTP and subsequent downstream signaling by the GTPase.
UniGene ID
Hs.368203
UniProt ID (eCommerce)
Q5JSL3
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.