human DNMT3L shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DNMT3L.
shAAV-207213
AAV-h-DNMT3L-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DNMT3L (DNA methyltransferase 3 like). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
29947
Gene Name (Vector)
DNA methyltransferase 3 like
Gene Symbol
DNMT3L
HGNC ID
HGNC:2980
ORF Size (aa)
1161
ORF Size (bp)
1161 bp
RefSeq ID
NM_013369
RefSeq Synonyms
NM_175867, NM_013369, BC002560,
Species
human
UniGene ID
Hs.592165
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.