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human DMWD shRNA silencing AAV

Name 
AAV-h-DMWD-shRNA
Cat No 
shAAV-207108
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human DMWD.

shAAV-207108
AAV-h-DMWD-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DMWD (dystrophia myotonica, WD repeat containing). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
D19S593E; DMRN9; DMR-N9; dystrophia myotonica WD repeat-containing protein; dystrophia myotonica, WD repeat containing; dystrophia myotonica-containing WD repeat motif protein; gene59; protein 59; Protein DMR-N9
Description (eCommerce)
The gene that codes for DMWD (dystrophia myotonica WD-repeat containing protein) is located in the myotonic dystrophy (DM1) gene cluster on 19q. Mutations in the DM1 region affect DMPK (myotonic dystrophy protein kinase), a myosin kinase expressed in skeletal muscle, and are the cause of myotonic dystrophy, a form of muscular dystrophy characterized by wasting of the muscles and myotonia. DMWD is expressed ubiquitously and is most abundant in the testes and brain. Studies concerning its abundance and sub-cellular localization in brain tissue suggest that it may have a role in some of the mental symptoms associated with myotonic dystrophy.
Gene ID
1762
Gene Name (eCommerce)
DM1 locus, WD repeat containing
Gene Name (Vector)
dystrophia myotonica, WD repeat containing
Gene Symbol
DMWD
HGNC ID
HGNC:2936
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2022
ORF Size (bp)
2022 bp
Protein Name (eCommerce)
Dystrophia myotonica WD repeat-containing protein
RefSeq ID
NM_004943
RefSeq Synonyms
NM_004943, BC156311, BC019266,
Research Areas
Cell Cycle,Meiosis
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics
Species
human
Target Sentence
The gene that codes for DMWD (dystrophia myotonica WD-repeat containing protein) is located in the myotonic dystrophy (DM1) gene cluster on 19q. Mutations in the DM1 region affect DMPK (myotonic dystrophy protein kinase), a myosin kinase expressed in skeletal muscle, and are the cause of myotonic dystrophy, a form of muscular dystrophy characterized by wasting of the muscles and myotonia. DMWD is expressed ubiquitously and is most abundant in the testes and brain. Studies concerning its abundance and sub-cellular localization in brain tissue suggest that it may have a role in some of the mental symptoms associated with myotonic dystrophy.
UniGene ID
Hs.515474
UniProt ID (eCommerce)
Q09019

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.