human DIO2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DIO2.
shAAV-206997
AAV-h-DIO2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DIO2 (iodothyronine deiodinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
5DII; D2; DIOII; SelY; TXDI2
Description (Vector)
DIO2 belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID
1734
Gene Name (Vector)
iodothyronine deiodinase 2
Gene Symbol
DIO2
HGNC ID
HGNC:2884
ORF Size (aa)
822
ORF Size (bp)
822 bp
RefSeq ID
NM_000793
RefSeq Synonyms
NM_013989, NM_001324462, NM_001242503, NM_001242502, NM_001007023, NM_000793, BC136514, BC074882,
Species
human
UniGene ID
Hs.708526
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.