human DHX8 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DHX8.
shAAV-206978
AAV-h-DHX8-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DHX8 (DEAH-box helicase 8). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATP-dependent RNA helicase DHX8; DDX8; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase); DEAH (Asp-Glu-Ala-His) box polypeptide 8; DEAH box protein 8; Dhr2; HRH1; PRP22; PRPF22; RNA helicase HRH1
Description (eCommerce)
DHX8 is a member of the DEAH box family of proteins that possesses several conserved motifs which include the highly conserved DEAH (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAH box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DHX8 is the human ortholog of the yeast Prp22 protein. DHX8 has been demonstrated to function in the release of RNA from the splicesome and the nuclear export of spliced mRNA.
Description (Vector)
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is highly homologous to yeast Prp22. This protein facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.
Gene ID
1659
Gene Name (eCommerce)
DEAH-box helicase 8
Gene Name (Vector)
DEAH-box helicase 8
Gene Symbol
DHX8
HGNC ID
HGNC:2749
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3663
ORF Size (bp)
3663 bp
Protein Name (eCommerce)
ATP-dependent RNA helicase DHX8
RefSeq ID
NM_004941
RefSeq Synonyms
NM_004941, NM_001322221, NM_001322220, NM_001322219, NM_001322218, NM_001322217, NM_001322216, NM_001302623, BC047327, BC044586,
Research Areas
Gene Expression,Helicase Activity,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,Spliceosome
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
DHX8 is a member of the DEAH box family of proteins that possesses several conserved motifs which include the highly conserved DEAH (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAH box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DHX8 is the human ortholog of the yeast Prp22 protein. DHX8 has been demonstrated to function in the release of RNA from the splicesome and the nuclear export of spliced mRNA.
UniGene ID
Hs.463105
UniProt ID (eCommerce)
Q14562
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.