human DHX33 shRNA silencing AAV

Name 
AAV-h-DHX33-shRNA
Cat No 
shAAV-206968
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human DHX33.

shAAV-206968
AAV-h-DHX33-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DHX33 (DEAH-box helicase 33). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ATP-dependent RNA helicase DHX33; DDX33; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 33; DEAH (Asp-Glu-Ala-His) box polypeptide 33; DEAH box protein 33; putative ATP-dependent RNA helicase DHX33
Description (eCommerce)
DHX33 is a member of the DEAH box family of proteins that possesses several conserved motifs which include the highly conserved DEAH (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAH box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. The specific function of DHX33 has not been determined.
Description (Vector)
DHX33 encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants.
Gene ID
56919
Gene Name (eCommerce)
DEAH-box helicase 33
Gene Name (Vector)
DEAH-box helicase 33
Gene Symbol
DHX33
HGNC ID
HGNC:16718
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1452
ORF Size (bp)
1452 bp
Protein Name (eCommerce)
Putative ATP-dependent RNA helicase DHX33
RefSeq ID
NM_020162
RefSeq Synonyms
NM_020162, NM_001199699, BC050409, BC042040,
Research Areas
Helicase Activity,RNA Processing,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
DHX33 is a member of the DEAH box family of proteins that possesses several conserved motifs which include the highly conserved DEAH (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAH box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. The specific function of DHX33 has not been determined.
UniGene ID
Hs.250456
UniProt ID (eCommerce)
Q9H6R0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.