Promotional banner reading 'FALL SAVINGS' with expiry date August 31 on an orange background; features a group of people with orange stacked blocks on the right and discounts for services and catalog products.

human DHX15 shRNA silencing AAV

Name 
AAV-h-DHX15-shRNA
Cat No 
shAAV-206959
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human DHX15.

shAAV-206959
AAV-h-DHX15-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DHX15 (DEAH-box helicase 15). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ATP-dependent RNA helicase #46; DBP1; DDX15; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15; DEAD/H box-15; DEAH (Asp-Glu-Ala-His) box helicase 15; DEAH (Asp-Glu-Ala-His) box polypeptide 15; DEAH box protein 15; HRH2; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; PRP43; PRPF43; PrPp43p; putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; RNA helicase 2
Description (eCommerce)
DHX15 is a member of the DEAH box family of proteins that possesses several conserved motifs which include the highly conserved DEAH (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAH box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DHX15 is the human ortholog of the yeast Prp43 protein. DHX15 has been demonstrated to function in ribosome biogenesis and pre-mRNA splicing.
Description (Vector)
DHX15 is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing.
Gene ID
1665
Gene Name (eCommerce)
DEAH-box helicase 15
Gene Name (Vector)
DEAH-box helicase 15
Gene Symbol
DHX15
HGNC ID
HGNC:2738
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2388
ORF Size (bp)
2388 bp
Protein Name (eCommerce)
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
RefSeq ID
NM_001358
RefSeq Synonyms
NM_001358, BC035974,
Research Areas
Gene Expression,Helicase Activity,Immunology,mRNA Processing,mRNA Splicing,RNA Processing,Spliceosome
Research Areas (Faceted)
genetics,transcription_translation,cell_biology,immunology
Species
human
Target Sentence
DHX15 is a member of the DEAH box family of proteins that possesses several conserved motifs which include the highly conserved DEAH (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAH box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DHX15 is the human ortholog of the yeast Prp43 protein. DHX15 has been demonstrated to function in ribosome biogenesis and pre-mRNA splicing.
UniGene ID
Hs.696074
UniProt ID (eCommerce)
O43143

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.