human DENND1C shRNA silencing AAV

Name
AAV-h-DENND1C-shRNA

Cat No
shAAV-206867

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human DENND1C.

shAAV-206867

AAV-h-DENND1C-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DENND1C (DENN domain containing 1C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

FAM31C

Description (Vector)

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1C, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 (PubMed 20154091)).(supplied by OMIM, Nov 2010)

Gene ID

79958

Gene Name (Vector)

DENN domain containing 1C

Gene Symbol

DENND1C

HGNC ID

HGNC:26225

ORF Size (aa)

2406

ORF Size (bp)

2406 bp

RefSeq ID

NM_024898

RefSeq Synonyms

NM_024898, NM_001290331, BC033437,

Species

human

UniGene ID

Hs.236449

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.