human DEGS1 shRNA silencing AAV

Name
AAV-h-DEGS1-shRNA

Cat No
shAAV-206860

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human DEGS1.

shAAV-206860

AAV-h-DEGS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DEGS1 (delta 4-desaturase, sphingolipid 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DEGS; DEGS-1; Des-1; DES1; FADS7; MIG15; MLD

Description (Vector)

DEGS1 encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor.

Gene ID

8560

Gene Name (Vector)

delta 4-desaturase, sphingolipid 1

Gene Symbol

DEGS1

HGNC ID

HGNC:13709

ORF Size (aa)

972

ORF Size (bp)

972 bp

RefSeq ID

NM_003676

RefSeq Synonyms

NM_003676, NM_001321542, NM_001321541, BC000961,

Species

human

UniGene ID

Hs.299878

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.