human DEFA5 shRNA silencing AAV

Name
AAV-h-DEFA5-shRNA

Cat No
shAAV-206798

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human DEFA5.

shAAV-206798

AAV-h-DEFA5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DEFA5 (defensin alpha 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DEF5; HD-5

Description (Vector)

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum.

Gene ID

1670

Gene Name (Vector)

defensin alpha 5

Gene Symbol

DEFA5

HGNC ID

HGNC:2764

ORF Size (aa)

285

RefSeq ID

NM_021010

RefSeq Synonyms

NM_021010, BC107079, BC069690,

Species

human

UniGene ID

Hs.655233

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.